Changes in mitochondrial components of hamster brown adipose tissue in response to cold acclimation.
نویسنده
چکیده
Cold acclimation of hamsters was found to result in an increase in cytochrome concentration relative to ATPase activity in brown adipose tissue mitochondria, but not in liver mitochondria. These data lend support to the hypothesis that the uncoupled respiration characteristic of non-shivering thermogenesis is the result of an adaptive change in the composition of brown adipose tissue mitochondria in response to cold acclimation.
منابع مشابه
Metabolic adaptations in brown adipose tissue of the hamster in extreme ambient temperatures.
Cold acclimation caused the following changes in the brown adipose tissue (BAT) of the hamster: the relative weight of the tissue increased, it color darkened, the multilocular structure predominated, and tissue protein content increased while fat content decreased. There was also an increase in the mitochondrial protein content. Heat acclimation had the opposite effects, i.e., the color became...
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The effect of acclimation at different temperatures on the act iv i ty of interscapular brown adipose tissue has been i nves t i ga ted in the hamster, a h ibernator . Between 3l ~ and ~~ the cytochrome oxidase act iv i ty of the tissue increased z~_ to 5-fold, mitochondrial GDP binding per mg of mitochondrial protein doubled, and the amount of uncoupling protein rose from 1.7% to 5.4% of total...
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In recent years, it has been shown that humans have active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitment of BAT can be a target to counterbalance the current obesity pandemic. Here, we show that a 10-day cold acclimation protocol in humans increases BAT activity in parallel with an increase in nonshivering thermogenesis (NST). No sex differences i...
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 194 2 شماره
صفحات -
تاریخ انتشار 1981